With Casualty approaching its 40th anniversary later this year, excitement is building among fans and critics alike. As the series continues its tradition of giving each 12-episode boxset a unique focus, attention is now turning to which characters will take centre stage in the next run of episodes.

The show’s strength has always been its ensemble storytelling, allowing a mix of seasoned veterans and newer cast members to anchor major arcs. As the milestone anniversary approaches, fans are eager to see which characters will carry the drama, emotion, and tension that Casualty is renowned for.

Here are five current characters that viewers most want to see in the spotlight:

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1. Rida Amaan

After surviving a traumatic ordeal with surgeon Russell in surgery, Rida returned to the ED with a promotion but has quietly struggled under the pressure. Her personal and professional challenges — including stress-related hair loss and fears about Holby’s future — make her prime for a storyline exploring her mental health and resilience. Fans are eager to see her rise as a leader while facing the emotional fallout of recent events.

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2. Rash Masum

One of the show’s longest-serving characters, Rash has quietly navigated a difficult period, including the fallout from his romance with pharmacist Sunny and his CESR pathway to becoming a consultant. Having survived past trauma, fans want to see Rash finally get a storyline that tests his professional skills and emotional strength, potentially positioning him at the heart of a high-stakes medical crisis.

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3. Flynn Byron

As clinical lead, Flynn has been pivotal in the department’s ongoing crises, from supporting colleagues to navigating inspections. Yet his military past and personal history remain largely unexplored, leaving a wealth of potential for the next boxset. Fans are hoping for a storyline that delves deeper into Flynn’s past and what makes him tick, while testing his leadership under pressure.

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4. Jan Jenning

Iconic as the manager of Holby ambulance station, Jan has been a mentor and moral compass for colleagues but hasn’t had a personal storyline in some time. Exploring her relationships, family life, or a potential romance could provide a compelling, character-driven arc for the upcoming episodes, giving one of the show’s most enduring characters a well-deserved spotlight.

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5. Indie Jankowski

The newest paramedic on the team, Indie has quickly become a fan favourite. While her romance with Cam and reunion with her estranged father Samuel have provided emotional beats, viewers are eager to see more of her personal journey and growth as a paramedic, cementing her presence as a key part of Holby ED’s next chapter.

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As the 40th anniversary approaches, these five characters represent the perfect mix of seasoned talent and rising stars to anchor the drama, deliver emotional depth, and captivate audiences. With Holby ED facing inspections, staff changes, and the ongoing pressures of emergency medicine, there’s plenty of scope for intense, character-driven storylines that will keep fans glued to their screens.

Casualty airs on Saturday nights on BBC One and streams first on BBC iPlayer, with episodes available from 6am on the day of transmission.